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Test Code SQ HTGRM, EPIC LAB3241 Thyroglobulin, Tumor Marker Reflex to LC-MS/MS or Immunoassay

Useful For

Reporting of accurate thyroglobulin results, depending on the anti-thyroglobulin antibodies status of the patient


Accurate measurement of serum thyroglobulin in patients with known or suspected anti-thyroglobulin autoantibodies or possible heterophile antibodies

Testing Algorithm

This test begins with the analysis of thyroglobulin antibody by immunoassay. If the thyroglobulin antibody result is negative (<4.0 IU/mL), thyroglobulin testing will be performed by immunoassay. If the thyroglobulin antibody result is positive (≥4.0 IU/mL), thyroglobulin testing will be performed by mass spectrometry.

Reporting Name

Thyroglobulin Reflex to MS or IA

Specimen Type

Serum Red

Specimen Required

Patient Preparation: For 12 hours before this test do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube: Red top

Submission Container/Tube: Aliquot vial

Specimen Volume: 1 mL


Specimen Minimum Volume

1.0 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 7 days
  Frozen  30 days

Reject Due To


Mild OK; Gross reject


Mild OK; Gross OK




Plasma, serum gel tube, whole blood

Reference Values

Thyroglobulin Antibody: <4.0 IU/mL

Day(s) and Time(s) Performed

TGABR and HTGT: Monday through Friday 6 a.m.-12 a.m., Saturday 6 a.m.-6 p.m.

TGMS: Monday through Friday, 4 p.m.

Analytic Time

1 day if thyroglobulin antibody result is negative or 2 to 3 days if positive

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HTGR Thyroglobulin Reflex to MS or IA 56536-6


Result ID Test Result Name Result LOINC Value
TGABR Thyroglobulin Antibody, S 56536-6

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HTGT Thyroglobulin, Tumor Marker, IA, S No No
TGMS Thyroglobulin, Mass Spec., S Yes No

Method Name

Immunoenzymatic Assay